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Papers and Publications

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  1. Wu, M.C., Cai, T., Lin, X. "Testing for regression coefficients in LASSO regularized regression".
    [*** An earlier version received an ENAR Student Paper Award ***]
  2. Li, L., Wu, M.C., Lin, X. "Prioritizing phenotype-associated uncommon variants in sequencing association studies".
  3. Zhao, N., Maity, A., Staicu, A.-M., Joubert, B.R., London, S.J., Wu, M.C.. "Global analysis of methylation profiles via a functional regression approach". Submitted.
  4. Wu, M.C., Joubert, B.R., Kuan, P.F., HÃ¥berg, S.E., Nystad, W., Peddada, S.D., London, S.J. "A systematic assessment of normalization approaches for the Infinium 450k methylation platform". Submitted.
  5. Engel, S.M.#, Joubert, B.R.#, Wu, M.C.#, Olshan, A.F., Haberg, S.E., Ueland, P.M., Nystad, W., Nilsen, R.M., Vollset, S.E., Peddada, S.D., London, S.J. "Neonatal genome-wide methylation patterns in relation to birthweight in the Norwegian Mother and Child Birth Cohort". [#Equal Contribution]
  6. Carroll, I.M., Ringel-Kulka, T., Ferrier, L., Wu, M.C., Siddle, J.P., Bueno, L., Ringel, Y. "Fecal protease activity is associated with compositional alterations in the intestinal microbiota".
  7. 2013

  8. Wu, M.C., Maity, A., Lee, S., Simmons, E.M., Harmon, Q.E., Lin, Xinyi, Engel, S.M., Molldrem, J.J., Armistead, P.M. (2013). "Kernel machine SNP-set testing under multiple candidate kernels". Genetic Epidemiology, 37(3): 267-75. PDF
  9. Byrnes, A.E., Wu, M.C., Wright, F.A., Li, M., Li, Y. (2013). "The value of statistical or bioinformatics annotation for rare variant association with quantitative trait". Genetic Epidemiology, To Appear.
  10. Harmon, Q.E., Engel, S.M., Olshan, A., Moran, T., Stuebe, A., Luo, J., Wu, M.C., Avery, C. (2013). "Polymorphisms in natural kill cell related genes are associated with preterm birth". American Journal of Epidemiology, To Appear.
  11. Cleary, S.P., Jeck, W.R., Zhao, X., Chen, K., Selitsky, S.R., Savich, G.L., Tan, T.X, Wu, M.C., Getz, G., Lawrence, M.S., Parker, J.S., Li, J, Powers, S., Kim, H., Fischer, S., Giundi, M., Ghanekar, A., Chiang, D.Y. (2013). "Identification of Driver Genes in Hepatocellular Carcinoma by Exome Sequencing". Hepatology, To Appear.
  12. Bailey, K.M., Wu, M.C., Ward, W.O., Smeester, L., Rager, J.E., Garcia-Varga, G., Del Razo, L., Drobna, Z., Styblo, M., Fry, R.C. (2013). "Inter-individual differences in arsenic metabolism and the epigenome: different patterns of DNA methylation". Journal of Biochemical and Molecular Toxicology, 27(2):106-115.
  13. Schuck, R.N., Theken, K.N., Edin, M.L., Caughey, M., Bass, A., Ellis, K., Tran, B., Steele, S., Simmons, B.P., Lih, B.P., Tomer, K.B., Wu, M.C., Hinderliter, A.L., Stouffer, G.A., Zeldin, D.R., Lee, C.R. (2013). "Cytochrome P450 derived eicosanoids and vascular function in coronary artery disease patients". Atherosclerosis, 227:442-48.
  14. 2012

  15. Lee, S., Wu, M.C., Lin, X. (2012). "Optimal tests for rare variant effects in sequencing association studies". Biostatistics, 13(4): 762-75. PDF
  16. Joubert, B.R., Haberg, S.E., Nilsen, R.M., Wang, X., Vollset, S.E., Murphey, S.K., Huang, Z., Hoyo, C., Midttun, O., Cupul-Uicab, L.A., Ueland, P.M., Wu, M.C., Nystad, W., Bell, D.A., Peddada, S.D., London, S.J. (2012). "450K Epigenome-Wide Scan Identifies Differential DNA Methylation in Newborns Related to Maternal Smoking During Pregnancy". Environmental Health Perspectives, 120: 1425-31.
  17. Wu, H., Wu, M.C., Zhi, D., Santorico, S.A., Cui, X. (2012). "Statistical analysis for next generation sequencing -- meeting report". Frontiers in Genetics, 3:128.
  18. Glickman, S.W., Shofer, F.S., Wu, M.C., Scholer, M.J., Ndubuizu, A., Cairns, C.B., Glickman, L.T. (2012). "Development and validation of a prioritization rule for obtaining an immediate 12-lead electrocardiogram in the emergency department to identify ST-elevation myocardial infarction". The American Heart Journal, 163(3): 372-382.
  19. Theken, K.N., Schuck, R.N., Edin, M.L., Tran, B., Ellis, K., Bass, A., Lih, F.B., Tomer, K.B., Poloyac, S.M., Wu, M.C., Hinderliter, A.L., Zeldin, D.C, Stouffer, G.A., Lee, C.R. (2012). "Evaluation of cytochrome P450-derived eicosanoids in humans with advanced cardiovascular disease". Atherosclerosis, 222(2): 530-536.
  20. 2011

  21. Wu, M.C.#, Lee, S.#, Cai, T., Li, Y., Boehnke, M., Lin, X. (2011). "Rare variant association testing for sequencing data with the sequence kernel association test (SKAT)". The American Journal of Human Genetics, 89, 82-93. PDF
    [#Equal Contribution]

  22. [*** This article selected by AJHG as one of the "Best of" 2011-2012 ***]
  23. Lin, X., Cai, T., Wu, M.C., Zhou, Q., Liu, G., Christiani, D.C., Lin, X. (2011). "Kernel machine SNP-set analysis for censored survival outcomes in genome-wide association studies". Genetic Epidemiology, 35, 620-31.
  24. Ter-Minassian, M., Wang, Z., Asomaning, K., Wu, M.C., Paulus, J.K., Liu, G., Bradbury, P.A., Zhai, R., Su, L., Frauenhoffer, C.S., Hooshman, S.M., De Vivo, I., Lin, X., Christiani, D.C., Kulke, M.H. (2011). "Genetic associations with sporadic neuroendocrine tumor risk". Carcinogenesis, 32(8):1216-22.
  25. 2010

  26. Wu, M.C., Kraft, P., Epstein, M.P., Taylor, D.M., Chanock, S.J., Hunter, D.J., and Lin, X. (2010). "Powerful SNP set analysis for case-control genome wide association studies". The American Journal of Human Genetics, 86, 929-942. PDF
  27. Locke, A.E., Dooley, K.J., Tinker, S.W., Cheong, S.Y., Feingold, E., Allen, E.G., Freeman, S.B., Torfs, C.P., Cua, C., Epstein, M.P., Wu, M.C., Lin, X., Capone, G., Sherman, S.L., Bean, L.J.H. (2010). "Variation in folate pathway genes contributes to risk of congenital heart defects among individuals with Down syndrome". Genetic Epidemiology, 34(6):613-23.
  28. Liu, C.Y., Wu, M.C., Chen, F., Ter-Minassian, M., Asomaning, K., Zhai, R., Wang, Z., Su, L., Heist, R.S., Kulke, M.H., Lin, X., Liu, G., Christiani, D.C. (2010). "A large-scale genetic association study of esophageal adenocarcinoma risk". Carcinogenesis, 31(7):1259-63.
  29. 2009 and earlier

  30. Wu, M.C., Zhang, L., Wang, Z., Christiani, D.C., Lin, X. (2009). "Sparse linear discriminant analysis for simultaneous gene set/pathway significance test and gene selection". Bioinformatics, 25,1145-1151. PDF
    [*** An earlier version received the 2008 ICSA Student Paper Award ***]
  31. Huang, Y.T., Heist, R.S., Chirieac, L.R., Lin, X., Skaug, V., Haugen, A., Wu, M.C., Wang, Z., Su, L., Asomaning, K., Christiani, D.C. (2009). "Genome-wide analysis of survival in early-stage non-small cell lung cancer". Journal of Clinical Oncology, 27(16):2660-2667.
  32. Wu, M.C., Lin, X. (2009). "Prior biological knowledge based approaches for the analysis of genome-wide expression profiles using gene sets and pathways". Statistical Methods in Medical Research,18(6):577-93. PDF
  33. Harezlak, J.#, Wu, M.C.#, Wang, M., Schwartzman, A., Christiani D.C., Lin, X. (2008). "Biomarker discovery for arsenic exposure using functional learning of mass-spectrometry proteomic data". Journal of Proteome Research, 7(1):217-24. PDF
    [#Equal Contribution]
  34. Engbring, J.A., Hossain, R., VanOsdol, S.J., Kaplan-Singer, B., Wu, M., Hibino, S., Koblinski, J.E. (2008). "The laminin alpha-1 chain derived peptide, AG73, increases fibronectin levels in breast and melanoma cancer cells". Clinical and Experimental Metastasis, 25(3):241-252
  35. Ji, H., Ramsey, M.R., Hayes, D.N., Fan, C., McNamara, K., Kozlowski, P., Torrice, C., Wu, M.C., Shimamura, T., Perera, S., Liang, M-C., Cai, D., Naumov, G.N., Bao, L., Contreras, C., Li, D., Chen, L., Krishnamurthy, J., Koivunen, J., Chirieac, L.R., Padera, R., Bronson, R.T., Lindeman, N.I., Christiani, D.C., Lin, X., Shapiro, G.I., Janne, P.A., Johnson, B., Meyerson, M., Kwiatkowski, D.J., Castrillon, D.H., Badeesy, N.,Sharpless, N.E., Wong, K-K. (2007). "LKB1 modulates lung cancer differentiation and metastasis". Nature, 448(7155):807-10.
  36. Koblinski, J.E., Wu, M., Demeler, B., Kleinman, H.K. (2005). "Matrix cell adhesion activation by non-adhesion proteins". Journal of Cell Science, 118(Pt 13):2965-74.
  37. Koblinski, J.E., Kaplan-Singer, B.R., VanOsdol, S.J., Wu, M., Engbring, J.A., Goldsmith, C.M., Piper, J.T., Vostal, J.G., Harms, J.F., Welch, D.R., Kleinman, H.K. (2005). "Endogenous osteonectin/SPARC/BM-40 expression inhibits MDA-MB-231 breast cancer cell metastasis". Cancer Research, 65(16):7370-7.
  38. Technical Reports

    All technical reports available upon request.
  39. Lee, S., Wu, M.C., Cai, T., Li, Y., Boehnke, M., Lin, X. (2011). "Power and sample size calculations for designing rare variant sequencing association studies". Technical Report, Harvard University. PDF
  40. Wu, M.C. (2009). "Statistical methods for high-dimensional genomic data". Ph.D. Dissertation, Harvard University.
  41. Wu, M.C., Zhang, L., Lin, X. (2008)."Two group classification using sparse linear discriminant analysis". Technical Report, Harvard University.
    [An earlier version won the 2008 ASA Statistical Computing and Graphics Section Student Paper Award]
  42. Wu, M.C., Lin, X. (2007). "Adaptively penalized logistic regression for testing the .significance of gene pathways". Technical Report, Harvard University.
  43. Wu, M.C., Neuberg, D.S., Manola, J., Vail, S. (2005). "Phase III randomized trial of interferon alfa-2b alone versus interferon alfa-2b plus thalidomide in patients with previously untreated metastatic or unresectable renal cell carcinoma". Technical Report 1128E of the Eastern Cooperative Oncology Group.