================================================================================ === HAPSTAT Analysis =================== C:\hapstat\data\cross-sectional.dat === ================================================================================ ================================================================================ Haplotype frequencies under Hardy-Weinberg equilibrium ================================================================================ Tolerance: 1e-006 Maximum iterations: 2000 Subjects: 5000 Haplotype Cross-sectional ---------------------------------- 000000 0.0300 000010 0.0408 000101 0.0011 000111 0.0002 001001 0.0003 001101 0.2990 001110 0.0004 010001 0.0002 010100 0.0007 010111 0.0001 011000 0.0069 011011 0.0653 011100 0.0012 100001 0.0002 100010 0.2447 101001 0.0006 101101 0.0909 101110 0.0000 110001 0.1482 110100 0.0004 110110 0.0004 111000 0.0435 111011 0.0242 111100 0.0004 111101 0.0002 ---------------------------------- Iterations 53 Log-Likelihood -16042.3231 ---------------------------------- Status: Success. ================================================================================ Additive haplotype effects under Hardy-Weinberg equilibrium ================================================================================ Tolerance: 0.0001 Maximum iterations: 500 Subjects: 4968/5000 Estimate StdError Z-Stat P-Value ---------------------------------------------------------- Effects ---------------------------------------------------------- Environment Age 0.0465 0.0012 37.4081 0.0000 Gender 0.5194 0.0280 18.5180 0.0000 Exposure 0.5656 0.0143 39.4964 0.0000 Gene 1 001 -0.1646 0.1607 -1.0242 0.3057 001*Age 0.0026 0.0035 0.7359 0.4618 001*Gender -0.0961 0.0807 -1.1899 0.2341 001*Exposure 0.0294 0.0408 0.7222 0.4702 Gene 2 101 -0.1382 0.0918 -1.5058 0.1321 101*Age -0.0007 0.0020 -0.3189 0.7498 101*Gender -0.2223 0.0456 -4.8717 0.0000 101*Exposure -0.0442 0.0228 -1.9396 0.0524 Genes 1*2 001*101 0.0780 0.0865 0.9017 0.3672 001*101*Age -0.0011 0.0019 -0.5802 0.5618 001*101*Gender 0.0185 0.0432 0.4278 0.6688 001*101*Exposure -0.0085 0.0219 -0.3870 0.6988 Intercept 1.4853 0.0562 26.4207 0.0000 Error variance 0.3817 0.0077 49.5871 0.0000 ---------------------------------------------------------- Frequencies ---------------------------------------------------------- 000000 0.0301 0.0017 17.2267 0.0000 000010 0.0412 0.0023 18.3045 0.0000 000101 0.0015 0.0004 3.7170 0.0002 001101 0.2993 0.0047 63.0271 0.0000 011000 0.0069 0.0010 6.9754 0.0000 011011 0.0654 0.0026 25.0187 0.0000 011100 0.0016 0.0004 3.8841 0.0001 100010 0.2454 0.0044 55.3723 0.0000 101101 0.0913 0.0031 29.1890 0.0000 110001 0.1488 0.0036 41.6317 0.0000 111000 0.0440 0.0021 20.7021 0.0000 111011 0.0244 0.0018 13.8913 0.0000 ---------------------------------------------------------- Iterations: 8 Log-Likelihood: -20379.6310 Status: Success. ==================== Report generated on 09/07/07 14:13:18 =====================