================================================================================ === HAPSTAT Analysis ====================== C:\hapstat\data\case-control.dat === ================================================================================ ================================================================================ Haplotype frequencies under Hardy-Weinberg equilibrium ================================================================================ Tolerance: 1e-006 Maximum iterations: 2000 Subjects: 2000 Cases: 1000 Controls: 1000 Haplotype Controls ---------------------------- 00011 0.0057 00100 0.0054 00110 0.0010 01011 0.1375 01100 0.2501 01101 0.0005 01110 0.0000 01111 0.0020 10000 0.0140 10011 0.3338 10100 0.0629 10110 0.0363 11011 0.1390 11100 0.0088 11111 0.0029 ---------------------------- Iterations 36 Log-Likelihood -2819.2358 ---------------------------- Status: Success. ================================================================================ Additive haplotype effects under Hardy-Weinberg equilibrium ================================================================================ Tolerance: 0.0001 Maximum iterations: 500 Subjects: 1997/2000 Cases: 999/1000 Controls: 998/1000 Estimate StdError Z-Stat P-Value ------------------------------------------------------ Effects ------------------------------------------------------ Environment Age 0.0320 0.0065 4.9140 0.0000 Gender 0.0797 0.1105 0.7213 0.4707 Gene 10011 0.0792 0.2301 0.3442 0.7307 10011*Age -0.0025 0.0059 -0.4251 0.6708 10011*Gender -0.1388 0.0992 -1.3988 0.1619 ------------------------------------------------------ Frequencies ------------------------------------------------------ 00011 0.0042 0.0013 3.2367 0.0012 00100 0.0044 0.0013 3.3158 0.0009 01011 0.1235 0.0057 21.6156 0.0000 01100 0.2957 0.0082 36.1758 0.0000 01111 0.0023 0.0008 2.7602 0.0058 10000 0.0108 0.0017 6.4417 0.0000 10011 0.3377 0.0109 30.8588 0.0000 10100 0.0563 0.0041 13.6649 0.0000 10110 0.0277 0.0026 10.4537 0.0000 11011 0.1267 0.0058 21.9841 0.0000 11100 0.0090 0.0019 4.7307 0.0000 11111 0.0017 0.0007 2.3963 0.0166 ------------------------------------------------------ Iterations: 4 Log-Likelihood: -6769.1064 Status: Success. ==================== Report generated on 09/07/07 14:02:14 ===================== ================================================================================ === HAPSTAT Analysis ====================== C:\hapstat\data\case-control.dat === ================================================================================ ================================================================================ Additive haplotype effects under Hardy-Weinberg equilibrium ================================================================================ Tolerance: 0.0001 Maximum iterations: 500 Subjects: 1997/2000 Cases: 999/1000 Controls: 998/1000 Estimate StdError Z-Stat P-Value ---------------------------------------------------------- Effects ---------------------------------------------------------- Environment Age 0.0270 0.0082 3.2808 0.0010 Gender -0.1531 0.1398 -1.0954 0.2733 Gene 01011 -0.3706 0.5188 -0.7144 0.4750 01100 0.4247 0.2420 1.7548 0.0793 11011 -0.2684 0.3644 -0.7366 0.4614 01011*Age 0.0035 0.0136 0.2586 0.7960 01100*Age -0.0011 0.0061 -0.1729 0.8627 11011*Age 0.0068 0.0092 0.7365 0.4615 01011*Gender -0.2068 0.6550 -0.3158 0.7522 01100*Gender 0.1227 0.1040 1.1803 0.2379 11011*Gender -0.0278 0.1550 -0.1792 0.8578 01011*Age*Gender 0.0139 0.0171 0.8105 0.4176 ---------------------------------------------------------- Frequencies ---------------------------------------------------------- 00011 0.0044 0.0014 3.2136 0.0013 00100 0.0048 0.0014 3.3248 0.0009 01011 0.1376 0.0082 16.7189 0.0000 01100 0.2507 0.0100 24.9852 0.0000 01111 0.0025 0.0009 2.7622 0.0057 10000 0.0116 0.0018 6.4264 0.0000 10011 0.3483 0.0099 35.1321 0.0000 10100 0.0605 0.0045 13.5599 0.0000 10110 0.0297 0.0029 10.3909 0.0000 11011 0.1384 0.0082 16.8628 0.0000 11100 0.0096 0.0020 4.6980 0.0000 11111 0.0018 0.0008 2.3684 0.0179 ---------------------------------------------------------- Iterations: 4 Log-Likelihood: -6745.0605 Status: Success. ==================== Report generated on 09/07/07 14:04:17 ===================== ================================================================================ === HAPSTAT Analysis ====================== C:\hapstat\data\case-control.dat === ================================================================================ ================================================================================ Additive haplotype effects under Hardy-Weinberg equilibrium ================================================================================ Tolerance: 0.0001 Maximum iterations: 500 Subjects: 1997/2000 Cases: 999/1000 Controls: 998/1000 Estimate StdError Z-Stat P-Value ----------------------------------------------------- Effects ----------------------------------------------------- Environment Age 0.0271 0.0079 3.4465 0.0006 Gender 0.0384 0.1335 0.2879 0.7734 Gene 1 100 0.1921 0.3125 0.6146 0.5388 100*Age -0.0093 0.0072 -1.2904 0.1969 100*Gender -0.1811 0.1224 -1.4799 0.1389 Gene 2 11 -0.7116 0.2654 -2.6814 0.0073 11*Age 0.0085 0.0066 1.2727 0.2031 11*Gender 0.0640 0.1122 0.5701 0.5686 Genes 1*2 100*11 0.2029 0.0839 2.4187 0.0156 ----------------------------------------------------- Frequencies ----------------------------------------------------- 00011 0.0045 0.0014 3.2227 0.0013 00100 0.0041 0.0013 3.3013 0.0010 01011 0.1350 0.0068 19.7197 0.0000 01100 0.2760 0.0091 30.2295 0.0000 01111 0.0025 0.0009 2.7569 0.0058 10000 0.0108 0.0018 5.9757 0.0000 10011 0.3396 0.0109 31.2749 0.0000 10100 0.0532 0.0040 13.2831 0.0000 10110 0.0259 0.0025 10.2689 0.0000 11011 0.1382 0.0069 19.9781 0.0000 11100 0.0082 0.0018 4.6735 0.0000 11111 0.0019 0.0008 2.3936 0.0167 ----------------------------------------------------- Iterations: 4 Log-Likelihood: -6757.3388 Status: Success. ==================== Report generated on 09/07/07 14:06:21 ===================== ================================================================================ === HAPSTAT Analysis ====================== C:\hapstat\data\case-control.dat === ================================================================================ ================================================================================ Additive haplotype effects under Hardy-Weinberg equilibrium ================================================================================ Tolerance: 0.0001 Maximum iterations: 500 Subjects: 1997/2000 Cases: 999/1000 Controls: 998/1000 Estimate StdError Z-Stat P-Value ----------------------------------------------------- Effects ----------------------------------------------------- Environment Age 0.0065 0.0186 0.3517 0.7251 Gender 0.0391 0.3131 0.1249 0.9006 Gene 1 1 -0.4339 0.4357 -0.9960 0.3192 1*Age 0.0027 0.0095 0.2813 0.7785 1*Gender -0.2046 0.1607 -1.2728 0.2031 Gene 2 1 -0.4100 0.3662 -1.1196 0.2629 1*Age 0.0103 0.0085 1.2016 0.2295 1*Gender 0.0391 0.1439 0.2720 0.7856 Gene 3 0 0.3557 1.0699 0.3325 0.7395 0*Age -0.0125 0.0239 -0.5242 0.6001 0*Gender -0.4782 0.4121 -1.1604 0.2459 Gene 4 1 -2.2380 1.0115 -2.2127 0.0269 1*Age 0.0410 0.0213 1.9243 0.0543 1*Gender 0.3422 0.3490 0.9805 0.3268 Gene 5 1 1.0510 1.4664 0.7167 0.4736 1*Age -0.0217 0.0318 -0.6836 0.4942 1*Gender 0.2380 0.5354 0.4446 0.6566 Genes 1*2 1*1 -0.0155 0.0915 -0.1696 0.8653 Genes 1*3 1*0 -0.0185 0.3795 -0.0487 0.9611 Genes 1*4 1*1 -0.0701 0.3423 -0.2047 0.8378 Genes 1*5 1*1 0.3717 0.5096 0.7293 0.4658 ----------------------------------------------------- Frequencies ----------------------------------------------------- 00011 0.0045 0.0014 3.1660 0.0015 00100 0.0038 0.0012 3.1193 0.0018 01011 0.1338 0.0077 17.4562 0.0000 01100 0.2574 0.0097 26.5795 0.0000 01111 0.0020 0.0009 2.2243 0.0261 10000 0.0126 0.0024 5.1621 0.0000 10011 0.3430 0.0106 32.5044 0.0000 10100 0.0582 0.0052 11.1937 0.0000 10110 0.0369 0.0043 8.5357 0.0000 11011 0.1369 0.0078 17.5067 0.0000 11100 0.0095 0.0021 4.5246 0.0000 11111 0.0015 0.0007 2.1696 0.0300 ----------------------------------------------------- Iterations: 5 Log-Likelihood: -6737.1485 Status: Success. ==================== Report generated on 09/07/07 14:09:05 ===================== ================================================================================ === HAPSTAT Analysis ====================== C:\hapstat\data\case-control.dat === ================================================================================ ================================================================================ Additive haplotype effects under Hardy-Weinberg equilibrium ================================================================================ Tolerance: 0.0001 Maximum iterations: 500 Subjects: 1997/2000 Cases: 999/1000 Controls: 998/1000 Estimate StdError Z-Stat P-Value ----------------------------------------------------- Effects ----------------------------------------------------- Environment Age 0.0238 0.0082 2.9154 0.0036 Gender 0.0235 0.1384 0.1700 0.8650 Gene 4 1 -0.5320 0.2115 -2.5157 0.0119 1*Age 0.0058 0.0054 1.0739 0.2829 1*Gender -0.0284 0.0908 -0.3126 0.7546 ----------------------------------------------------- Frequencies ----------------------------------------------------- 00011 0.0045 0.0014 3.2383 0.0012 00100 0.0040 0.0012 3.3019 0.0010 01011 0.1332 0.0061 21.7613 0.0000 01100 0.2686 0.0092 29.0992 0.0000 01111 0.0025 0.0009 2.7609 0.0058 10000 0.0098 0.0015 6.3865 0.0000 10011 0.3498 0.0090 38.9967 0.0000 10100 0.0511 0.0039 13.1353 0.0000 10110 0.0299 0.0029 10.4794 0.0000 11011 0.1367 0.0062 22.2094 0.0000 11100 0.0081 0.0017 4.6944 0.0000 11111 0.0019 0.0008 2.3972 0.0165 ----------------------------------------------------- Iterations: 4 Log-Likelihood: -6756.9357 Status: Success. ==================== Report generated on 09/07/07 14:09:43 =====================