This directory contains files for simulating a single trial according to the two-dimensional 
design described in "Two-dimensional dose finding in discrete dose space" (Wang and Ivanova, 
2005, Biometrics, 61, 217-222). Users have options to generate subjects’ responses according 
to scenarios 1, 2, 3, 4 or 5, that are presented in the paper, or to input subjects’ responses 
that are actually observed. Design parameters are specified in the function main (trial2.cpp) 
and include the numbers of dose levels, target toxicity rate, and the total number of subjects 
in the trial. These design parameters can be changed as needed. The following files are included:

rand.cpp: functions for generating random numbers
trial_estimation.cpp: functions for estimating the parameters in the working model
trial_crm2.cpp : all other functions for the two-dimensional design
trial.h, rand.h, trial_estimation.h: header functions and global variables 

Note: The c++ programs are tested with Microsoft Visual C++ 6.0 compiler on Windows XP operating system. 
To save the results of a simulated trial, use the DOS command “filename.exe > filename.doc”.