Cox regression for PBC data (Dummy Stratification) 1 15:20 Friday, May 9, 2008 The PHREG Procedure Model Information Data Set WORK.A Dependent Variable time Censoring Variable delta Censoring Value(s) 0 Ties Handling BRESLOW Number of Observations Read 312 Number of Observations Used 312 Class Level Information Class Value Design Variables stage 1 1 0 0 2 0 1 0 3 0 0 1 4 0 0 0 Summary of the Number of Event and Censored Values Percent Total Event Censored Censored 312 125 187 59.94 Convergence Status Convergence criterion (GCONV=1E-8) satisfied. Model Fit Statistics Without With Criterion Covariates Covariates -2 LOG L 1279.960 1118.826 AIC 1279.960 1134.826 SBC 1279.960 1157.452 Testing Global Null Hypothesis: BETA=0 Test Chi-Square DF Pr > ChiSq Likelihood Ratio 161.1342 8 <.0001 Score 273.5412 8 <.0001 Wald 175.9121 8 <.0001 Type 3 Tests Wald Effect DF Chi-Square Pr > ChiSq sex 1 4.5119 0.0337 age 1 6.9967 0.0082 edema 1 23.0006 <.0001 Cox regression for PBC data (Dummy Stratification) 2 15:20 Friday, May 9, 2008 The PHREG Procedure Type 3 Tests Wald Effect DF Chi-Square Pr > ChiSq trt 1 0.0979 0.7543 bili 1 75.7414 <.0001 stage 3 24.1493 <.0001 Analysis of Maximum Likelihood Estimates Parameter Standard Parameter DF Estimate Error Chi-Square Pr > ChiSq sex 1 -0.54023 0.25433 4.5119 0.0337 age 1 0.02527 0.00956 6.9967 0.0082 edema 1 1.40269 0.29248 23.0006 <.0001 trt 1 0.05832 0.18638 0.0979 0.7543 bili 1 0.13136 0.01509 75.7414 <.0001 stage 1 1 -2.55575 1.01733 6.3113 0.0120 stage 2 1 -1.03638 0.28814 12.9369 0.0003 stage 3 1 -0.74218 0.20583 13.0022 0.0003 Analysis of Maximum Likelihood Estimates Hazard Parameter Ratio Label sex 0.583 age 1.026 edema 4.066 trt 1.060 bili 1.140 stage 1 0.078 Stage of disease 1 stage 2 0.355 Stage of disease 2 stage 3 0.476 Stage of disease 3 Cox regression for PBC data (true stratification) 3 15:20 Friday, May 9, 2008 The PHREG Procedure Model Information Data Set WORK.A Dependent Variable time Censoring Variable delta Censoring Value(s) 0 Ties Handling BRESLOW Number of Observations Read 312 Number of Observations Used 312 Summary of the Number of Event and Censored Values Percent Stratum stage Total Event Censored Censored 1 1 16 1 15 93.75 2 2 67 16 51 76.12 3 3 120 43 77 64.17 4 4 109 65 44 40.37 ------------------------------------------------------------------- Total 312 125 187 59.94 Convergence Status Convergence criterion (GCONV=1E-8) satisfied. Model Fit Statistics Without With Criterion Covariates Covariates -2 LOG L 989.447 882.927 AIC 989.447 892.927 SBC 989.447 907.068 Testing Global Null Hypothesis: BETA=0 Test Chi-Square DF Pr > ChiSq Likelihood Ratio 106.5206 5 <.0001 Score 177.6107 5 <.0001 Wald 124.0892 5 <.0001 Analysis of Maximum Likelihood Estimates Parameter Standard Hazard Parameter DF Estimate Error Chi-Square Pr > ChiSq Ratio sex 1 -0.51860 0.25639 4.0915 0.0431 0.595 age 1 0.02665 0.00948 7.9063 0.0049 1.027 edema 1 1.27336 0.29162 19.0663 <.0001 3.573 trt 1 -0.00212 0.18767 0.0001 0.9910 0.998 bili 1 0.14572 0.01678 75.4434 <.0001 1.157