' 09:48 Monday, May 12, 2008 1 proc lifereg: pooled sample The LIFEREG Procedure Model Information Data Set WORK.A Dependent Variable Log(time) Follow-up time (weeks) Censoring Variable delta Event: 0=censored 1=observed Censoring Value(s) 0 Number of Observations 42 Noncensored Values 30 Right Censored Values 12 Left Censored Values 0 Interval Censored Values 0 Name of Distribution Exponential Log Likelihood -57.25126709 Number of Observations Read 42 Number of Observations Used 42 Fit Statistics -2 Log Likelihood 114.503 AIC (smaller is better) 116.503 AICC (smaller is better) 116.603 BIC (smaller is better) 118.240 Algorithm converged. Analysis of Maximum Likelihood Parameter Estimates Standard 95% Confidence Chi- Parameter DF Estimate Error Limits Square Pr > ChiSq Intercept 1 2.8922 0.1826 2.5344 3.2501 250.95 <.0001 Scale 0 1.0000 0.0000 1.0000 1.0000 Weibull Scale 1 18.0333 3.2924 12.6086 25.7919 Weibull Shape 0 1.0000 0.0000 1.0000 1.0000 Lagrange Multiplier Statistics Parameter Chi-Square Pr > ChiSq Scale 0.9020 0.3422 ' 09:48 Monday, May 12, 2008 2 proc lifereg: by group (exponential) Group: 0=control 1=drug=0 The LIFEREG Procedure Model Information Data Set WORK.A Dependent Variable Log(time) Follow-up time (weeks) Censoring Variable delta Event: 0=censored 1=observed Censoring Value(s) 0 Number of Observations 21 Noncensored Values 21 Right Censored Values 0 Left Censored Values 0 Interval Censored Values 0 Name of Distribution Exponential Log Likelihood -28.02162781 Number of Observations Read 21 Number of Observations Used 21 Fit Statistics -2 Log Likelihood 56.043 AIC (smaller is better) 58.043 AICC (smaller is better) 58.254 BIC (smaller is better) 59.088 Algorithm converged. Analysis of Maximum Likelihood Parameter Estimates Standard 95% Confidence Chi- Parameter DF Estimate Error Limits Square Pr > ChiSq Intercept 1 2.1595 0.2182 1.7318 2.5872 97.93 <.0001 Scale 0 1.0000 0.0000 1.0000 1.0000 Weibull Scale 1 8.6667 1.8912 5.6507 13.2923 Weibull Shape 0 1.0000 0.0000 1.0000 1.0000 ' 09:48 Monday, May 12, 2008 3 proc lifereg: by group (exponential) Group: 0=control 1=drug=0 The LIFEREG Procedure Lagrange Multiplier Statistics Parameter Chi-Square Pr > ChiSq Scale 5.6285 0.0177 ' 09:48 Monday, May 12, 2008 4 proc lifereg: by group (exponential) Group: 0=control 1=drug=1 The LIFEREG Procedure Model Information Data Set WORK.A Dependent Variable Log(time) Follow-up time (weeks) Censoring Variable delta Event: 0=censored 1=observed Censoring Value(s) 0 Number of Observations 21 Noncensored Values 9 Right Censored Values 12 Left Censored Values 0 Interval Censored Values 0 Name of Distribution Exponential Log Likelihood -20.9870319 Number of Observations Read 21 Number of Observations Used 21 Fit Statistics -2 Log Likelihood 41.974 AIC (smaller is better) 43.974 AICC (smaller is better) 44.185 BIC (smaller is better) 45.019 Algorithm converged. Analysis of Maximum Likelihood Parameter Estimates Standard 95% Confidence Chi- Parameter DF Estimate Error Limits Square Pr > ChiSq Intercept 1 3.6861 0.3333 3.0328 4.3394 122.29 <.0001 Scale 0 1.0000 0.0000 1.0000 1.0000 Weibull Scale 1 39.8888 13.2963 20.7547 76.6628 Weibull Shape 0 1.0000 0.0000 1.0000 1.0000 ' 09:48 Monday, May 12, 2008 5 proc lifereg: by group (exponential) Group: 0=control 1=drug=1 The LIFEREG Procedure Lagrange Multiplier Statistics Parameter Chi-Square Pr > ChiSq Scale 1.9466 0.1630 ' 09:48 Monday, May 12, 2008 6 proc lifereg: by group (weibull) Group: 0=control 1=drug=0 The LIFEREG Procedure Model Information Data Set WORK.A Dependent Variable Log(time) Follow-up time (weeks) Censoring Variable delta Event: 0=censored 1=observed Censoring Value(s) 0 Number of Observations 21 Noncensored Values 21 Right Censored Values 0 Left Censored Values 0 Interval Censored Values 0 Name of Distribution Weibull Log Likelihood -26.59256617 Number of Observations Read 21 Number of Observations Used 21 Fit Statistics -2 Log Likelihood 53.185 AIC (smaller is better) 57.185 AICC (smaller is better) 57.852 BIC (smaller is better) 59.274 Algorithm converged. Analysis of Maximum Likelihood Parameter Estimates Standard 95% Confidence Chi- Parameter DF Estimate Error Limits Square Pr > ChiSq Intercept 1 2.2494 0.1678 1.9205 2.5783 179.67 <.0001 Scale 1 0.7297 0.1266 0.5192 1.0253 Weibull Scale 1 9.4821 1.5912 6.8244 13.1750 Weibull Shape 1 1.3705 0.2379 0.9753 1.9259 ' 09:48 Monday, May 12, 2008 7 proc lifereg: by group (weibull) Group: 0=control 1=drug=1 The LIFEREG Procedure Model Information Data Set WORK.A Dependent Variable Log(time) Follow-up time (weeks) Censoring Variable delta Event: 0=censored 1=observed Censoring Value(s) 0 Number of Observations 21 Noncensored Values 9 Right Censored Values 12 Left Censored Values 0 Interval Censored Values 0 Name of Distribution Weibull Log Likelihood -20.47083008 Number of Observations Read 21 Number of Observations Used 21 Fit Statistics -2 Log Likelihood 40.942 AIC (smaller is better) 44.942 AICC (smaller is better) 45.608 BIC (smaller is better) 47.031 Algorithm converged. Analysis of Maximum Likelihood Parameter Estimates Standard 95% Confidence Chi- Parameter DF Estimate Error Limits Square Pr > ChiSq Intercept 1 3.5194 0.2734 2.9836 4.0552 165.75 <.0001 Scale 1 0.7387 0.2057 0.4280 1.2748 Weibull Scale 1 33.7652 9.2303 19.7595 57.6980 Weibull Shape 1 1.3537 0.3769 0.7844 2.3362 ' 09:48 Monday, May 12, 2008 8 proc lifereg: model time * delta (0) = group The LIFEREG Procedure Model Information Data Set WORK.A Dependent Variable Log(time) Follow-up time (weeks) Censoring Variable delta Event: 0=censored 1=observed Censoring Value(s) 0 Number of Observations 42 Noncensored Values 30 Right Censored Values 12 Left Censored Values 0 Interval Censored Values 0 Name of Distribution Weibull Log Likelihood -47.06410176 Number of Observations Read 42 Number of Observations Used 42 Fit Statistics -2 Log Likelihood 94.128 AIC (smaller is better) 100.128 AICC (smaller is better) 100.760 BIC (smaller is better) 105.341 Algorithm converged. Type III Analysis of Effects Wald Effect DF Chi-Square Pr > ChiSq group 1 16.6444 <.0001 Analysis of Maximum Likelihood Parameter Estimates Standard 95% Confidence Chi- Parameter DF Estimate Error Limits Square Pr > ChiSq Intercept 1 2.2484 0.1660 1.9231 2.5737 183.51 <.0001 group 1 1.2673 0.3106 0.6585 1.8762 16.64 <.0001 Scale 1 0.7322 0.1078 0.5486 0.9772 Weibull Shape 1 1.3658 0.2012 1.0233 1.8228