The SAS System 09:42 Monday, May 12, 2008 1 The CONTENTS Procedure Data Set Name WORK.GAMMA Observations 128 Member Type DATA Variables 20 Engine V9 Indexes 0 Created Monday, May 12, 2008 09:42:22 AM Observation Length 160 Last Modified Monday, May 12, 2008 09:42:22 AM Deleted Observations 0 Protection Compressed NO Data Set Type Sorted NO Label Data Representation WINDOWS_32 Encoding wlatin1 Western (Windows) Engine/Host Dependent Information Data Set Page Size 16384 Number of Data Set Pages 2 First Data Page 1 Max Obs per Page 102 Obs in First Data Page 84 Number of Data Set Repairs 0 Filename C:\DOCUME~1\cai\LOCALS~1\Temp\SAS Temporary Files\_TD2840\gamma.sas7bdat Release Created 9.0201M0 Host Created XP_PRO Alphabetic List of Variables and Attributes # Variable Type Len 6 age Num 8 2 center Num 8 14 event1 Num 8 15 event2 Num 8 16 event3 Num 8 17 event4 Num 8 18 event5 Num 8 19 event6 Num 8 20 event7 Num 8 13 futime Num 8 7 height Num 8 12 hos_cat Num 8 1 id Num 8 9 inherit Num 8 11 propylac Num 8 3 random Num 8 4 rx Num 8 5 sex Num 8 10 steroids Num 8 8 weight Num 8 The SAS System 09:42 Monday, May 12, 2008 2 s p i t r h c r h w n e o o f e e e e e e e e a e e h r p s u v v v v v v v n n i i e o y _ t e e e e e e e O t d s a g g r i l c i n n n n n n n b i e o r e g h h i d a a m t t t t t t t s d r m x x e t t t s c t e 1 2 3 4 5 6 7 1 1 204 10467 1 2 12 147.0 62.0 2 2 2 2 414 219 373 . . . . . 2 2 204 10467 0 1 15 159.0 47.5 2 2 1 2 439 8 26 152 241 249 322 350 3 3 204 10468 1 1 19 171.0 72.7 1 2 1 2 382 . . . . . . . 4 4 204 10483 1 1 12 142.0 34.0 1 2 1 2 388 . . . . . . . 5 5 238 10498 0 1 17 162.5 52.7 1 2 1 1 383 246 253 . . . . . 6 6 245 10500 1 2 44 153.3 45.0 2 2 2 2 364 . . . . . . . 7 7 245 10500 0 1 22 175.0 59.7 1 2 1 2 364 292 . . . . . . 8 8 245 10500 1 1 7 111.0 17.4 1 2 1 2 363 . . . . . . . 9 9 238 10504 0 1 27 176.0 82.8 2 2 1 1 349 294 . . . . . . 10 10 238 10504 1 1 5 113.0 19.5 1 2 1 1 371 . . . . . . . The SAS System 09:42 Monday, May 12, 2008 3 s p i t r h g c r h w n e o o t s a e a e e h r p s s t t p e n n i i e o y _ t e s a t n O t d s a g g r i l c a n t t r r r i u b i e o r e g h h i d a a r u o u x x x m m s d r m x x e t t t s c t t m p s 1 2 3 e 3 1 1 204 10467 1 2 12 147.0 62.0 2 2 2 2 0 1 219 1 1 0 0 219 1 2 1 204 10467 1 2 12 147.0 62.0 2 2 2 2 219 2 373 1 0 1 0 154 2 3 1 204 10467 1 2 12 147.0 62.0 2 2 2 2 373 3 414 0 0 0 1 41 3 4 2 204 10467 0 1 15 159.0 47.5 2 2 1 2 0 1 8 1 0 0 0 8 1 5 2 204 10467 0 1 15 159.0 47.5 2 2 1 2 8 2 26 1 0 0 0 18 2 6 2 204 10467 0 1 15 159.0 47.5 2 2 1 2 26 3 152 1 0 0 0 126 3 7 2 204 10467 0 1 15 159.0 47.5 2 2 1 2 152 4 241 1 0 0 0 89 3 8 2 204 10467 0 1 15 159.0 47.5 2 2 1 2 241 5 249 1 0 0 0 8 3 9 2 204 10467 0 1 15 159.0 47.5 2 2 1 2 249 6 322 1 0 0 0 73 3 10 2 204 10467 0 1 15 159.0 47.5 2 2 1 2 322 7 350 1 0 0 0 28 3 11 2 204 10467 0 1 15 159.0 47.5 2 2 1 2 350 8 439 0 0 0 0 89 3 12 3 204 10468 1 1 19 171.0 72.7 1 2 1 2 0 1 382 0 1 0 0 382 1 13 4 204 10483 1 1 12 142.0 34.0 1 2 1 2 0 1 388 0 1 0 0 388 1 14 5 238 10498 0 1 17 162.5 52.7 1 2 1 1 0 1 246 1 0 0 0 246 1 15 5 238 10498 0 1 17 162.5 52.7 1 2 1 1 246 2 253 1 0 0 0 7 2 16 5 238 10498 0 1 17 162.5 52.7 1 2 1 1 253 3 383 0 0 0 0 130 3 17 6 245 10500 1 2 44 153.3 45.0 2 2 2 2 0 1 364 0 1 0 0 364 1 18 7 245 10500 0 1 22 175.0 59.7 1 2 1 2 0 1 292 1 0 0 0 292 1 19 7 245 10500 0 1 22 175.0 59.7 1 2 1 2 292 2 364 0 0 0 0 72 2 20 8 245 10500 1 1 7 111.0 17.4 1 2 1 2 0 1 363 0 1 0 0 363 1 The SAS System 09:42 Monday, May 12, 2008 4 s p k i t r h e c r h w n e o o s e e a e e h r p s t e p n n i i e o y _ t a e n d O t d s a g g r i l c i t n r r r u a b i e o r e g h h i d a a m u u x x x m t s d r m x x e t t t s c t i e s m 1 2 3 3 a 1 1 204 10467 1 2 12 147 62.0 2 2 2 2 1 219 1 1 1 0 0 1 1 2 1 204 10467 1 2 12 147 62.0 2 2 2 2 2 373 1 2 0 1 0 2 1 3 1 204 10467 1 2 12 147 62.0 2 2 2 2 3 414 0 3 0 0 1 3 1 4 1 204 10467 1 2 12 147 62.0 2 2 2 2 4 414 0 4 0 0 1 3 0 5 1 204 10467 1 2 12 147 62.0 2 2 2 2 5 414 0 5 0 0 1 3 0 6 1 204 10467 1 2 12 147 62.0 2 2 2 2 6 414 0 6 0 0 1 3 0 7 1 204 10467 1 2 12 147 62.0 2 2 2 2 7 414 0 7 0 0 1 3 0 8 2 204 10467 0 1 15 159 47.5 2 2 1 2 1 8 1 1 0 0 0 1 1 9 2 204 10467 0 1 15 159 47.5 2 2 1 2 2 26 1 2 0 0 0 2 1 10 2 204 10467 0 1 15 159 47.5 2 2 1 2 3 152 1 3 0 0 0 3 1 11 2 204 10467 0 1 15 159 47.5 2 2 1 2 4 241 1 4 0 0 0 3 1 12 2 204 10467 0 1 15 159 47.5 2 2 1 2 5 249 1 5 0 0 0 3 1 13 2 204 10467 0 1 15 159 47.5 2 2 1 2 6 322 1 6 0 0 0 3 1 14 2 204 10467 0 1 15 159 47.5 2 2 1 2 7 350 1 7 0 0 0 3 1 15 3 204 10468 1 1 19 171 72.7 1 2 1 2 1 382 0 1 1 0 0 1 1 16 3 204 10468 1 1 19 171 72.7 1 2 1 2 2 382 0 2 0 1 0 2 0 17 3 204 10468 1 1 19 171 72.7 1 2 1 2 3 382 0 3 0 0 1 3 0 18 3 204 10468 1 1 19 171 72.7 1 2 1 2 4 382 0 4 0 0 1 3 0 19 3 204 10468 1 1 19 171 72.7 1 2 1 2 5 382 0 5 0 0 1 3 0 20 3 204 10468 1 1 19 171 72.7 1 2 1 2 6 382 0 6 0 0 1 3 0 Time to first event 09:42 Monday, May 12, 2008 5 The PHREG Procedure Model Information Data Set SAVE.CGD1 Dependent Variable tstop Censoring Variable status Censoring Value(s) 0 Ties Handling BRESLOW Number of Observations Read 128 Number of Observations Used 128 Summary of the Number of Event and Censored Values Percent Total Event Censored Censored 128 44 84 65.63 Convergence Status Convergence criterion (GCONV=1E-8) satisfied. Model Fit Statistics Without With Criterion Covariates Covariates -2 LOG L 388.234 371.713 AIC 388.234 379.713 SBC 388.234 386.850 Testing Global Null Hypothesis: BETA=0 Test Chi-Square DF Pr > ChiSq Likelihood Ratio 16.5202 4 0.0024 Score 16.2816 4 0.0027 Wald 15.0687 4 0.0046 Time to first event 09:42 Monday, May 12, 2008 6 The PHREG Procedure Analysis of Maximum Likelihood Estimates Parameter Standard Hazard Parameter DF Estimate Error Chi-Square Pr > ChiSq Ratio rx 1 -1.15709 0.34074 11.5318 0.0007 0.314 age 1 -0.03438 0.01842 3.4849 0.0619 0.966 inherit 1 0.25558 0.33711 0.5748 0.4484 1.291 steroids 1 -0.91180 0.73059 1.5576 0.2120 0.402 Andersen-Gill Intensity Model 09:42 Monday, May 12, 2008 7 The PHREG Procedure Model Information Data Set SAVE.CGD1 Dependent Variable tstart Dependent Variable tstop Censoring Variable status Censoring Value(s) 0 Ties Handling BRESLOW Number of Observations Read 203 Number of Observations Used 203 Summary of the Number of Event and Censored Values Percent Total Event Censored Censored 203 76 127 62.56 Convergence Status Convergence criterion (GCONV=1E-8) satisfied. Model Fit Statistics Without With Criterion Covariates Covariates -2 LOG L 684.577 653.337 AIC 684.577 661.337 SBC 684.577 670.660 Testing Global Null Hypothesis: BETA=0 Test Chi-Square DF Pr > ChiSq Likelihood Ratio 31.2400 4 <.0001 Score 30.6473 4 <.0001 Wald 28.3293 4 <.0001 Andersen-Gill Intensity Model 09:42 Monday, May 12, 2008 8 The PHREG Procedure Analysis of Maximum Likelihood Estimates Parameter Standard Hazard Parameter DF Estimate Error Chi-Square Pr > ChiSq Ratio rx 1 -1.10198 0.26255 17.6160 <.0001 0.332 age 1 -0.03959 0.01400 7.9971 0.0047 0.961 inherit 1 0.38235 0.24554 2.4248 0.1194 1.466 steroids 1 -1.05966 0.52737 4.0374 0.0445 0.347 PWP2 (conditional model: total time) 09:42 Monday, May 12, 2008 9 The PHREG Procedure Model Information Data Set SAVE.CGD1 Dependent Variable tstart Dependent Variable tstop Censoring Variable status Censoring Value(s) 0 Ties Handling BRESLOW Number of Observations Read 203 Number of Observations Used 203 Summary of the Number of Event and Censored Values Percent Stratum enum3 Total Event Censored Censored 1 1 128 44 84 65.63 2 2 44 17 27 61.36 3 3 31 15 16 51.61 ------------------------------------------------------------------- Total 203 76 127 62.56 Convergence Status Convergence criterion (GCONV=1E-8) satisfied. Model Fit Statistics Without With Criterion Covariates Covariates -2 LOG L 529.201 507.202 AIC 529.201 531.202 SBC 529.201 559.171 Testing Global Null Hypothesis: BETA=0 Test Chi-Square DF Pr > ChiSq Likelihood Ratio 21.9994 12 0.0375 Score 21.3729 12 0.0452 Wald 19.6502 12 0.0740 PWP2 (conditional model: total time) 09:42 Monday, May 12, 2008 10 The PHREG Procedure Analysis of Maximum Likelihood Estimates Parameter Standard Hazard Parameter DF Estimate Error Chi-Square Pr > ChiSq Ratio rx1 1 -1.15709 0.34073 11.5319 0.0007 0.314 rx2 1 0.25707 0.59473 0.1868 0.6656 1.293 rx3 1 -1.44682 1.04856 1.9039 0.1676 0.235 age1 1 -0.03438 0.01842 3.4850 0.0619 0.966 age2 1 -0.03008 0.02960 1.0321 0.3097 0.970 age3 1 -0.03147 0.04649 0.4581 0.4985 0.969 inherit1 1 0.25558 0.33711 0.5748 0.4484 1.291 inherit2 1 -0.02337 0.56742 0.0017 0.9671 0.977 inherit3 1 0.08512 0.58702 0.0210 0.8847 1.089 steroids1 1 -0.91127 0.73076 1.5550 0.2124 0.402 steroids2 1 -1.38387 1.19875 1.3327 0.2483 0.251 steroids3 1 0.00200 1.36253 0.0000 0.9988 1.002 PWP2 (conditional model: total time with common effect) 11 09:42 Monday, May 12, 2008 The PHREG Procedure Model Information Data Set SAVE.CGD1 Dependent Variable tstart Dependent Variable tstop Censoring Variable status Censoring Value(s) 0 Ties Handling BRESLOW Number of Observations Read 203 Number of Observations Used 203 Summary of the Number of Event and Censored Values Percent Stratum enum3 Total Event Censored Censored 1 1 128 44 84 65.63 2 2 44 17 27 61.36 3 3 31 15 16 51.61 ------------------------------------------------------------------- Total 203 76 127 62.56 Convergence Status Convergence criterion (GCONV=1E-8) satisfied. Model Fit Statistics Without With Criterion Covariates Covariates -2 LOG L 529.201 512.081 AIC 529.201 520.081 SBC 529.201 529.404 Testing Global Null Hypothesis: BETA=0 Test Chi-Square DF Pr > ChiSq Likelihood Ratio 17.1207 4 0.0018 Score 16.2784 4 0.0027 Wald 15.6270 4 0.0036 PWP2 (conditional model: total time with common effect) 12 09:42 Monday, May 12, 2008 The PHREG Procedure Analysis of Maximum Likelihood Estimates Parameter Standard Hazard Parameter DF Estimate Error Chi-Square Pr > ChiSq Ratio rx 1 -0.91720 0.28100 10.6537 0.0011 0.400 age 1 -0.03241 0.01424 5.1803 0.0228 0.968 inherit 1 0.24467 0.24893 0.9660 0.3257 1.277 steroids 1 -0.70721 0.55119 1.6462 0.1995 0.493 PWP3 (conditional model: gap time) 09:42 Monday, May 12, 2008 13 The PHREG Procedure Model Information Data Set SAVE.CGD1 Dependent Variable gaptime Censoring Variable status Censoring Value(s) 0 Ties Handling BRESLOW Number of Observations Read 203 Number of Observations Used 203 Summary of the Number of Event and Censored Values Percent Stratum enum3 Total Event Censored Censored 1 1 128 44 84 65.63 2 2 44 17 27 61.36 3 3 31 15 16 51.61 ------------------------------------------------------------------- Total 203 76 127 62.56 Convergence Status Convergence criterion (GCONV=1E-8) satisfied. Model Fit Statistics Without With Criterion Covariates Covariates -2 LOG L 568.834 551.115 AIC 568.834 559.115 SBC 568.834 568.438 Testing Global Null Hypothesis: BETA=0 Test Chi-Square DF Pr > ChiSq Likelihood Ratio 17.7193 4 0.0014 Score 17.0275 4 0.0019 Wald 16.2648 4 0.0027 PWP3 (conditional model: gap time) 09:42 Monday, May 12, 2008 14 The PHREG Procedure Analysis of Maximum Likelihood Estimates Parameter Standard Hazard Parameter DF Estimate Error Chi-Square Pr > ChiSq Ratio rx 1 -0.92123 0.27950 10.8633 0.0010 0.398 age 1 -0.03007 0.01405 4.5802 0.0323 0.970 inherit 1 0.21112 0.25137 0.7054 0.4010 1.235 steroids 1 -0.87691 0.54389 2.5995 0.1069 0.416 Proportional Means Model 09:42 Monday, May 12, 2008 15 The PHREG Procedure Model Information Data Set SAVE.CGD1 Dependent Variable tstart Dependent Variable tstop Censoring Variable status Censoring Value(s) 0 Ties Handling BRESLOW Number of Observations Read 203 Number of Observations Used 203 Summary of the Number of Event and Censored Values Percent Total Event Censored Censored 203 76 127 62.56 Convergence Status Convergence criterion (GCONV=1E-8) satisfied. Model Fit Statistics Without With Criterion Covariates Covariates -2 LOG L 684.577 653.337 AIC 684.577 661.337 SBC 684.577 670.660 Testing Global Null Hypothesis: BETA=0 Test Chi-Square DF Pr > ChiSq Likelihood Ratio 31.2400 4 <.0001 Score (Model-Based) 30.6473 4 <.0001 Score (Sandwich) 11.9972 4 0.0174 Wald (Model-Based) 28.3293 4 <.0001 Wald (Sandwich) 21.6360 4 0.0002 Proportional Means Model 09:42 Monday, May 12, 2008 16 The PHREG Procedure Analysis of Maximum Likelihood Estimates Parameter Standard StdErr Hazard Parameter DF Estimate Error Ratio Chi-Square Pr > ChiSq Ratio rx 1 -1.10198 0.30846 1.175 12.7630 0.0004 0.332 age 1 -0.03959 0.01481 1.058 7.1498 0.0075 0.961 inherit 1 0.38235 0.32060 1.306 1.4224 0.2330 1.466 steroids 1 -1.05966 0.58768 1.114 3.2513 0.0714 0.347